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目标蛋白的 UniProt 登录号： P59594

目标的替代名称：刺突蛋白；S蛋白；SARS-CoV S蛋白；S糖蛋白；E2; Peplomer 蛋白; 尖峰蛋白 S1 
免疫原：原始抗体是通过对 GD03-RBD-C9、两个非免疫人类 Ab 噬菌体展示文库进行淘选产生的，并针对假型病毒测试了中和活性。

特异性：该抗体与 SARS-CoV Spike 蛋白 (GD03) 的 S1 域中的氨基酸 472 和 480 特异性结合。

应用说明：该抗体通过与 GD03 病毒株刺突蛋白 S1 结构域上的特定氨基酸结合，抑制 SARS-CoV S 蛋白与血管紧张素转化酶 2 (ACE2) 受体的结合。11A 有效抑制 GD03-RBD 与表达 ACE2 的 293T 细胞的结合。11A IgG 与 GD03-RBD 结合的动力学分析表明高亲和力相互作用 (KD = 2.260.7 nM)。D480A 或 D480G 位置的单个氨基酸变化导致 11A 结合*丧失。（隋等人，2008）

抗体发表于： 隋等人。扩大中和活性以直接阻断显性抗体驱动的 SARS-冠状病毒进化途径。PLoS 病原体。(2008); 4（11）：e1000197。 PMID:18989460 
发表 说明：描述了通过使用链改组和热点 CDR 突变的组合来产生广泛中和抗体的方法。