现货moradec AH-101-AF说明书

更新时间：2022-12-28

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现货moradec AH-101-AF说明书

αHFc NC MMAF

抗人IgG Fc MMAF抗体与不可裂解连接子

目录号：AH-101-AF

αHFc NC MMAF是一种抗人IgG Fc特异性抗体，其与单甲基auristatin F（MMAF）结合，具有不可裂解的接头。抗体部分是对人IgG的Fc区特异的多克隆抗体。单甲基auristatin F（MMAF）是一种细胞毒性小分子，通过阻断微管蛋白的聚合来抑制细胞分裂。连接MMAF和抗体的不可裂解接头在细胞外液中是稳定的，但在进入细胞时可以通过未指明的机制裂解。

αHFc-NC-MMAF

Anti-human IgG Fc-MMAF Antibody with Non-Cleavable Linker

Catalog Number: AH-101-AF

αHFc-NC-MMAF is anti-human IgG Fc specific antibody conjugated to monomethyl auristatin F (MMAF) with a non-cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Monomethyl auristatin F (MMAF) is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The non-cleavable linker connecting MMAF to the antibody is stable in extracellular fluid, but can be cleaved by unspecified mechanisms upon entering cells.

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