signalchemlifesciences——激酶研究
SignalChem Lifesciences Corporation (“SLC”)公司总部位于加拿大不列颠哥伦比亚，是激酶研究领域的企业，其两大核心产品系列为生物试剂及研究服务与药物研发服务部。生物试剂及研究服务（SignalChem Pharmaceuticals Inc）始于2004年，致力于研发和生产生物医药研究和药物研发领域的激酶产品，目前拥有的激酶/表观遗传相关酶类及其检测试剂产品超过2000种，覆盖几乎所有激酶靶点以及表观遗传研究相关酶类，以及多种信号蛋白相关产品。同时，为辅助检测激酶及临床疾病和个体化治疗，SignalChem还在生物标志物及诊断试剂盒领域有着数十年的积淀，拥有强大和丰富的相关产品。药物研发服务部致力于寻找新的小分子激酶抑制剂，并用于临床治疗。凭借公司丰富的激酶特异性小分子复合物资源库，以及公司在激酶研究领域强大研究团队和丰富研究经验，SLC在以激酶及其通路为靶点的药物设计、研发和生产具有*优势，目前公司已拥有大量的以激酶为靶点的小分子抑制剂产品，可用于研究各种肿瘤等疾病。蛋白激酶是联结所有细胞活动的中枢，通过过表达/过度激活及突变蛋白激酶可导致机体功能异常进而引发疾病，因此靶向激酶的药物有着重要的临床应用价值。蛋白激酶家族是仅次于G蛋白偶联受体家族的第二大药物靶点，目前已发现约518种野生型的激酶族以及与其相关的临床突变案例，有超过30种FDA认证的激酶抑制剂。凭借着多年来以激酶为核心的细胞信号相关产品研发积累，以及为科研院所及制药企业科研服务经验，SignalChem在抑制激酶活性的药物领域处于水平，公司不仅拥有zui大的且不断成长的活性激酶及突变激酶产品线，以及可在多个检测平台实施的激酶活性检测试剂盒，而且不断与多个大型制药企业和研究院所广泛合作，公司的主要产及服务包括：
1、凭借公司强大的科研力量和经验，SignalChem推出的“Kinome Search Engine”激酶筛选系统，可对每一个激酶族中的单个激酶做出检测，从而辅助和加快激酶药物的研发。
2、“Kinome Search Engine”激酶筛选系统不仅可辅助设计激酶药物，还可进一步研究人类激酶族的功能和机制，加深对未知激酶的认识，寻找更多的药物靶点，（目前认证的药物仅仅有少于5%是以已知的激酶通路为靶点，因此激酶通路作为药物靶点有着巨大的潜力和价值）。
3、SignalChem公司拥有激酶相关临床突变数据库，在研究疾病复发和抗药领域的核心问题时有着的优势，可以更为有效地协助制药企业进行药物研发。
除了药物研发方面的优势，SignalChem还在生物标志物及诊断试剂盒领域有着数十年的积淀，拥有强大和丰富的相关产品。
目前SLC公司的产品覆盖了几乎所有细胞内激酶相关通路，包括AKT/PKB通路、ERK/MAPK通路、JAK/STAT通路、JNK/SAPK通路、NfkB通路、p38通路、PKA/PKC通路、WNT信号通路等，适用于血管再生、凋亡和自噬、肿瘤、心血管疾病、细胞周期、细胞应激、胞内酪氨酸激酶、炎症、浸润和转移、脂质激酶、代谢性疾病、神经生物学、磷酸酶/磷酸二酯酶、受体酪氨酸激酶、Ser/Thr激酶等研究领域。主要产品有：
一、蛋白酶类产品系列
1、高活性乙酰转移酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
KAT2A (GCN5), Active | K311-381G | Human | GST tag | Sf9 insect cells | 323-end | NM_021078 |
KAT2B (PCAF), Active | K311-381BG | Human | GST tag | Sf9 insect cells | 431-end | NM_003884 |
KAT3A (CREBBP), Active | K312-381G | Human | GST tag | Sf9 insect cells | 1319-1710 | NM_004380 |
KAT5 (TIP60), Active | K314-380G | Human | GST tag | Sf9 insect cells | Full Length | NM_006388 |
KAT6B (MYST4), Active | K315-381BG | Human | GST tag | Sf9 insect cells | 431-end | NM_012330 |
KAT7 (MYST2), Active | K316-380G | Human | GST tag | Sf9 insect cells | Full Length | NM_007067 |
2、高活性精氨酸脱亚氨酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
PAD Cocktail, Active | P312-37C | - | - | - | Full Length | - |
3、高活性GTP/ATP酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
CDC42, Active | C108-310GH | Human | GST/His | E.coli | Full length | NM_001791 |
GNAI1, Active | G121-310G | Human | GST tag | E.coli | 2-end | NM_002069 |
GNAI2, Active | G122-310G | Human | GST tag | E.coli | 2-end | NM_002070 |
GNAI3, Active | G123-310G | Human | GST tag | E.coli | 2-end | NM_006496 |
GNAS, Active | G127-310G | Human | GST tag | E.coli | Full length | NM_000516 |
HRAS1 (Mature form), Active | R105-310H | Human | His tag | E.coli | 2-186 | NM_005343 |
KRAS (Mature form), Active | R106-310H | Human | His tag | E.coli | 2-186 | NM_033360 |
NRAS (Mature form), Active | R107-310H | Human | His tag | E.coli | 2-186 | NM_002524 |
RAC1, Active | R103-310G | Human | GST tag | E.coli | Full length | NM_006908 |
RAC2, Active | R104-310H | Human | His tag | E.coli | Full length | NM_002872 |
RAC3, Active | R102-310H | Human | His tag | E.coli | Full length | NM_005052 |
RhoA (Mature form), Active | R144-310H | Human | His tag | E.coli | 1-190 | NM_001664 |
RhoC (Mature form), Active | R144-310CH | Human | His tag | E.coli | 1-190 | NM_175744 |
RhoD (Mature form), Active | R144-310DH | Human | His tag | E.coli | 1-207 | BC001338 |
VCP, Active | V116-310G | Human | GST tag | Sf9 insect cells | Full length | NM_007126 |
4、高活性组蛋白去乙酰化酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
HDAC1, Active | H83-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_004964 |
HDAC10, Active | H92-31G | Human | GST tag | Sf9 insect cells | 1-482 | NM_032019 |
HDAC11, Active | H93-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_024827 |
HDAC2, Active | H84-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_001527 |
HDAC3, Active | H85-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_003883 |
HDAC3/NCOR2, Active | H85-38G | Human | GST tags | Sf9 insect cells | HDAC3 (full-length)/ NCOR2 (237-489) | NM_003883 |
HDAC4, Active | H86-31G | Human | GST tag | Sf9 insect cells | 612-end | NM_006037 |
HDAC5, Active | H87-31G | Mouse | GST tag | Sf9 insect cells | 617-end | BC060609 |
HDAC6, Active | H88-30G | Human | GST tag | Sf9 insect cells | Full Length | BC069243 |
HDAC7, Active | H89-31G | Human | GST tag | Sf9 insect cells | 501-end | NM_015401 |
HDAC8, Active | H90-30H | Human | His tag | Sf9 insect cells | Full Length | BC050433 |
5、活性突变激酶（共计253种）
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
ABL1 Mutant (E255K), Active | A03-12BG | Human | GST tag | Sf9 insect cells | 27-end (E255K) | NM_005157 |
ABL1 Mutant (E255V), Active | A03-12HH | Human | His tag | Sf9 insect cells | 27-end (E255V) | NM_005157 |
ABL1 Mutant (F317I), Active | A03-12JG | Human | GST tag | Sf9 insect cells | 27-end (F317I) | NM_005157 |
ABL1 Mutant (F317L), Active | A03-12IG | Human | GST tag | Sf9 insect cells | 27-end (F317L) | NM_005157 |
ABL1 Mutant (G250E), Active | A03-12CG | Human | GST tag | Sf9 insect cells | 27-end (G250E) | NM_005157 |
ABL1 Mutant (H396P), Active | A03-12LG | Human | GST tag | Sf9 insect cells | 27-end (H396P) | NM_005157 |
ABL1 Mutant (M351T), Active | A03-12KG | Human | GST tag | Sf9 insect cells | 27-end (M351T) | NM_005157 |
ABL1 Mutant (Q252H), Active | A03-12FG | Human | GST tag | Sf9 insect cells | 27-end (Q252H) | NM_005157 |
ABL1 Mutant (T315I), Active | A03-12DG | Human | GST tag | Sf9 insect cells | 27-end (T315I) | NM_005157 |
ABL1 Mutant (V299L), Active | A03-12MG | Human | GST tag | Sf9 insect cells | 27-end (V299L) | NM_005157 |
ABL1 Mutant (Y253F), Active | A03-12EG | Human | GST tag | Sf9 insect cells | 27-end (Y253F) | NM_005157 |
ABL1 Mutant (Y253H), Active | A03-12GH | Human | His tag | Sf9 insect cells | 27-end (Y253H) | NM_005157 |
AKT1 Mutant (E17K), Active | A16-12G | Human | GST tag | Sf9 insect cells | Full length (E17K) | NM_005163 |
AKT2 Mutant (E17K), Active | A17-12G | Human | GST tag | Sf9 insect cells | Full length (E17K) | NM_001626 |
AKT2 Mutant (R274H), Active | A17-12BG | Human | GST tag | Sf9 insect cells | Full length (R274H) | NM_001626 |
AKT3 Mutant (E17K), Active | A18-12G | Human | GST tag | Sf9 insect cells | Full Length (E17K) | NM_005465 |
AKT3 Mutant (G171R), Active | A18-12BG | Human | GST tag | Sf9 insect cells | Full length (G171R) | NM_005465 |
ALK Mutant (C1156Y), Active | A19-12DG | Human | GST tag | Sf9 insect cells | 1060-end (C1156Y) | NM_004304 |
ALK Mutant (F1174L), Active | A19-12EG | Human | GST tag | Sf9 insect cells | 1060-end (F1174L) | NM_004304 |
ALK Mutant (F1174S), Active | A19-12FG | Human | GST tag | Sf9 insect cells | 1060-end (F1174S) | NM_004304 |
ALK Mutant (G1202R), Active | A19-12HG | Human | GST tag | Sf9 insect cells | 1060-end (G1202R) | NM_004304 |
ALK Mutant (G1269A), Active | A19-12JG | Human | GST tag | Sf9 insect cells | 1060-end (G1269A) | NM_004304 |
ALK Mutant (G1269S), Active | A19-12KG | Human | GST tag | Sf9 insect cells | 1060-end (G1269S) | NM_004304 |
ALK Mutant (L1152R), Active | A19-12CG | Human | GST tag | Sf9 insect cells | 1060-end (L1152R) | NM_004304 |
ALK Mutant (L1196M), Active | A19-12GG | Human | GST tag | Sf9 insect cells | 1060-end (L1196M) | NM_004304 |
ALK Mutant (R1275Q), Active | A19-12LG | Human | GST tag | Sf9 insect cells | 1060-end (R1275Q) | NM_004304 |
ALK Mutant (S1206R), Active | A19-12IG | Human | GST tag | Sf9 insect cells | 1060-end (S1206R) | NM_004304 |
ALK Mutant (T1151M), Active | A19-12BG | Human | GST tag | Sf9 insect cells | 1060-end (T1151M) | NM_004304 |
ALK Mutant (T1151_L1152insT), Active | A19-12G | Human | GST tag | Sf9 insect cells | 1060-end (T1151_L1152insT) | NM_004304 |
ALK2 Mutant (PF197_198L), Active | A06-12FG | Human | GST tag | Sf9 insect cells | 147-end (PF197_198L) | NM_001105 |
ALK2 Mutant (Q207D), Active | A06-13CG | Human | GST tag | Sf9 insect cells | 147-end (Q207D) | NM_001105 |
ALK2 Mutant (Q207E), Active | A06-13DG | Human | GST tag | Sf9 insect cells | 147-end (Q207E) | NM_001105 |
ALK2 Mutant (R206H), Active | A06-12BG | Human | GST tag | Sf9 insect cells | 147-end (R206H) | NM_001105 |
ALK3 Mutant (Q233D), Active | B04-12BG | Human | GST tag | Sf9 insect cells | 187-end (Q233D) | NM_004329 |
ALK3 Mutant (R486Q), Active | B04-12CG | Human | GST tag | Sf9 insect cells | 187-end (R486Q) | NM_004329 |
AXL Mutant (R499C), Active | A34-12BG | Human | GST tag | Sf9 insect cells | 473-end (R499C) | NM_021913 |
BCR-RET Mutant, Active | R02-19EG | Human | GST tag | Sf9 insect cells | 1-426 (BCR) - 713-end (RET) | BC066122 |
BRAF Mutant (d485-489 P490Y), Active | B08-12IG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (d485-489 P490Y) | NM_004333 |
BRAF Mutant (G464V), Active | B08-12JG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (G464V) | NM_004333 |
BRAF Mutant (G469A), Active | B08-12FG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (G469A) | NM_004333 |
BRAF Mutant (K601E), Active | B08-12BG | Human | GST tag | Sf9 insect cells | 416-end (K601E) | NM_004333 |
BRAF Mutant (L597V), Active | B08-12HG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (L597V) | NM_004333 |
BRAF Mutant (R506_K507insVLR), Active | B08-13CG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (R506_K507insVLR) | NM_004333 |
6、活性激酶
该产品系列共包括445种激酶产品，下表仅列部分.
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
ABL1, Active | A03-11H | Mouse | His tag | Sf9 insect cells | 27-end | NM_009594 |
ABL1, Active | A03-18H | Human | His tag | Sf9 insect cells | 27-end | NM_005157 |
ABL2, Active | A04-11H | Human | His tag | Sf9 insect cells | 38-end | NM_005158 |
ACK, Active | A05-11G | Human | GST tag | Sf9 insect cells | 110-476 | NM_005781 |
AKT1, Active | A16-10G | Human | GST tag | Sf9 insect cells | Full Length | NM_005163 |
AKT2, Active | A17-10H | Human | His tag | Sf9 insect cells | Full Length | NM_001626 |
AKT2, Active | A17-10G | Human | GST tag | Sf9 insect cells | Full Length | NM_001626 |
AKT3, Active | A18-10G | Human | GST tag | Sf9 insect cells | Full Length | NM_005465 |
7、高活脂质激酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
DGKA, Active | D21-10G | Human | GST tag | Sf9 insect cells | Full length | NM_001345 |
PI3K (p110 alpha (E545K)/p85 alpha), Active | P27-152H | Human | His tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha (N345K(/p85 alpha), Active | P27-122CH | Human | His tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha(E542K)/p85 alpha, Active | P27-122DH | Human | His tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha/p55 gamma), Active | P27-102CH | Human | His tag | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha/p85 alpha), Active | P27-102G | Human | GST tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha/p85 alpha), Active | P27-102H | Human | His tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha/p85 alpha), Active | P27-182H | Mouse | His tags | Sf9 insect cells | Full length | NM_008839 |
PI3K (p110 beta/p85 alpha), Active | P28-102H | Human | His tags | Sf9 insect cells | Full length | NM_006219 |
PI3K (p110 beta/p85 beta), Active | P28-102BH | Human | His tags | Sf9 insect cells | Full length | NM_006219 |
PI3K (p110 delta/p85 alpha), Active | P30-102H | Human | His tags | Sf9 insect cells | Full length | NM_005026 |
PI3K (p120 gamma), Active | P29-102H | Human | His tag | Sf9 insect cells | Full length | NM_002649 |
PI4K2A, Active | P21-102G | Human | GST tag | Sf9 insect cells | Full length | NM_018425 |
PI4K2B, Active | P22-102G | Human | GST tag | Sf9 insect cells | Full length | NM_018323 |
PI4KA, Active | P31-102G | Human | GST tag | Sf9 insect cells | Full length | NM_002650 |
PI4KB, Active | P32-102G | Human | GST tag | Sf9 insect cells | Full length | BC000029 |
PIK3C2A, Active | P23-112G | Human | GST tag | Sf9 insect cells | 299-end | NM_002645 |
PIK3C2B, Active | P24-112BG | Human | GST tag | Sf9 insect cells | 850-end | BC144342 |
8、高活性甲基转移酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
COMT, Active | C339-381G | Human | GST tag | Sf9 insect cells | 27-271 | NM_000754 |
DNMT3A, Active | D353-380G | Human | GST tag | Sf9 insect cells | Full Length | BC043617 |
DNMT3B, Active | D353-380BG | Human | GST tag | Sf9 insect cells | Full Length | BC111933 |
DNMT3L, Active | D353-380CG | Human | GST tag | Sf9 insect cells | Full Length | BC002560 |
DOT1L (KMT4), Active | D344-381G | Human | GST tag | Sf9 insect cells | 1-435 | NM_032482 |
EHMT1 (KMT1D), Active | E317-381G | Human | GST tag | Sf9 insect cells | 895-end | NM_024757 |
EHMT2, Active | E318-381G | Human | GST tag | Sf9 insect cells | 807-end | NM_006709 |
LCMT1, Active | L321-380G | Human | GST tag | Sf9 insect cells | Full length | NM_016309 |
MLL1 (KMT2A), Active | M341-381G | Human | GST tag | Sf9 insect cells | 3738-end | NM_005933 |
MLL2 (KMT2D), Active | M342-381G | Human | GST tag | Sf9 insect cells | 5317-end | NM_003482 |
MLL3 (KMT2C), Active | M343-381G | Human | GST tag | Sf9 insect cells | 4689-end | NM_170606 |
9、高活性磷酸酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
CDC2, Active | C04-20G | Human | GST tag | Sf9 insect cells | Full Length | NM_001789 |
CDC25B, Active | C04-20BG | Human | GST tag | Sf9 insect cells | Full Length | NM_021873 |
CDC25C, Active | C04-20CG | Human | GST tag | Sf9 insect cells | Full Length | BC019089 |
DUSP22 (MKPX), Active | D22-20G | Human | GST tag | E.coli | Full Length | NM_020185 |
PP1A, Active | P13-20G | Human | GST tag | Sf9 insect cells | Full Length | NM_002708 |
PP1B, Active | P14-20G | Human | GST tag | Sf9 insect cells | Full Length | NM_002709 |
PP2A alpha/PPP2R1A Complex, Active | P16-20BH | Human | His tags | Sf9 insect cells | Full length | NM_002715 |
PP2Aalpha, Active | P16-20G | Human | GST tag | Sf9 insect cells | Full Length | NM_002715 |
10、高活性磷酸二酯酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 | 基因号 |
PDE10A, Active | P98-31G | Human | GST tag | Sf9 insect cells | 71-end | NM_006661 |
PDE1A, Active | P89-30H | Human | His tag | Sf9 insect cells | Full Length | NM_005019 |
PDE1B, Active | P89-30BG | Human | GST tag | Sf9 insect cells | Full Length | NM_000924 |
PDE1C, Active | P89-30CG | Human | GST tag | Sf9 insect cells | Full Length | NM_005020 |
PDE2A, Active | P90-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_002599 |
PDE3A, Active | P91-31G | Human | GST tag | Sf9 insect cells | 669-end | NM_000921 |
PDE3B, Active | P91-31BG | Human | GST tag | Sf9 insect cells | 654-end | NM_000922 |
PDE4A, Active | P92-31G | Human | GST tag | Sf9 insect cells | 332-end | NM_001111307 |
PDE4B, Active | P92-31BG | Human | GST tag | Sf9 insect cells | 305-end | NM_002600 |
PDE4C, Active | P92-31CG | Human | GST tag | Sf9 insect cells | 287-end | NM_000923 |
11、高活性蛋白酶
品名 | 货号 | 种属 | 标记类型 | 表达系统 | 氨基序列 |
CPB (carboxypeptidase B), Active | C560-31N | Rat | tag-free | Yeast cells | 109-end |
EK (enterokinase), Active | E535-31H | Swine | His tag | Yeast cells | 800-end |
Immobilized Lys-c, Agarose | L585-31AN | Bacteria | tag-free | E.coli | 206-473 aa |
Immobilized Lys-c, Silica | L585-31SN | Bacteria | tag-free | E.coli | 206-473 aa |
Immobilized Thrombin, Agarose | T565-31AN | Human | Native |
|
|
Immobilized Trypsin, Agarose | T575-31AN | Swine | tag-free | Yeast cells | 10-end |
Immobilized Trypsin, Silica | T575-31SN | Swine | tag-free | Yeast cells | 10-end |
KEX2 Protease, Active | K525-31N | Yeast | tag-free | Yeast cells | 110-660 aa |
Lys-c (lysyl-endopeptidase), Active | L585-31N | Bacteria | tag-free | E.coli | 206-473 aa |
二、抗体产品系列
1、亚型特异性抗体
品名 | 货号 | 宿主 | 应用 |
Anti-AKT3 | A18-63R | Rabbit | WB |
Anti-AMPK alpha 1 | P47-63R | Rabbit | WB |
Anti-CAMK1 | C07-60M | Mouse, IgG1, 5H8 | WB |
Anti-CHK2 | C48-60M | Mouse, IgG1, 7F9 | WB |
Anti-ERK1 | M29-60M | Mouse, IgG1, E32 | WB, IP |
Anti-ERK1 | M29-60BM | Mouse, IgG1, E19 | WB, IP |
Anti-GSK3 alpha | G08-63R | Rabbit | WB |
Anti-GSK3 beta | G09-60M | Mouse, IgG1, 6C2 | WB |
Anti-HSP90 beta | H36-63R | Rabbit | WB |
2、偶联修饰的抗体
品名 | 货号 | 宿主 | 应用 |
Anti-5-Methylated Cytosine (5-methyl cytosine) | C92-67S | Sheep, IgG | WB, IP |
Anti-Acetylated Lysine | L95-66R | Rabbit | WB, ELISA, PI, IHC, IF |
Anti-Acetylated Lysine, Biotin Conjugated | L95-66BR | Rabbit | WB, ELISA, IF, IHC, IP |
Anti-Acetylated Lysine, FITC Conjugated | L95-66CR | Rabbit | For direct immunofluorescence assay |
Anti-Acetylated Lysine, HRP Conjugated | L95-66DR | Rabbit | WB, ELISA, IF, IHC, IP |
Anti-Methylated Arginine (NG, NG-Di-methyl) | A96-67R | Rabbit | WB, ELISA, IF, IHC, IP |
Anti-Methylated Arginine (NG-Mono-methyl) | A95-67R | Rabbit | WB, ELISA, IF, IHC, IP |
Anti-Methylated Lysine (Tri- epsilon-N-methyl) | L95-67R | Rabbit | WB, ELISA, IF, IHC, IP |
3、磷酸化特异性抗体
该产品系列共包括82款磷酸化特异性抗体，下表仅列部分产品，
品名 | 货号 | 宿主 | 应用 |
Anti-phospho-14-3-3 beta (Ser58) | Y71-365R | Rabbit, IgG | WB, IHC |
Anti-phospho-4EBP1 (Thr45) | E35-365R | Rabbit, IgG | WB, IHC |
Anti-phospho-AKT1/2/3 (Ser473) | A16-65BR | Rabbit, IgG | WB, IHC |
Anti-phospho-AKT1/2/3 (Thr308) | A16-65R | Rabbit, IgG | WB, IHC |
Anti-phospho-ASK1 (Ser966) | M13-65R | Rabbit, IgG | IHC |
Anti-phospho-ATF2 (Ser112) | A10-565R | Rabbit, IgG | IHC |
Anti-phospho-ATF2 (Ser490 Ser498) | A10-565BR | Rabbit, IgG | WB, IHC |
Anti-phospho-BRCA1 (Ser1423) | B87-365R | Rabbit, IgG | IHC |
Anti-phospho-c-KIT (Tyr721) | K06-65R | Rabbit, IgG | WB |
Anti-phospho-c-KIT (Tyr936) | K06-65BR | Rabbit, IgG | IHC |
4、Primary Antibodies
该产品系列共包括279款原初抗体，下表仅列部分产品
品名 | 货号 | 宿主 | 应用 |
Anti-4EBP1 | E35-563R | Rabbit, IgG | WB, ELISA, ICC |
Anti-ADD1 | A38-63R | Rabbit | WB |
Anti-AFX | A42-63R | Rabbit | WB |
Anti-AKT (pan) | A16-63R | Rabbit | WB |
Anti-AKT (pan) | A16-63BR | Rabbit | WB |
Anti-AKT1 | A16-60M | Mouse, Monoclonal, 9A4 | WB |
Anti-AKT1 | A16-63CR | Rabbit, IgG | WB, ELISA, IF, IHC |
Anti-AKT2/3 | A17-63BR | Rabbit | WB |
Anti-ALK2 | A06-63R | Rabbit, IgG | WB, ELISA |
Anti-ALK4 | A07-63R | Rabbit, IgG | WB, ELISA |
5、二抗
品名 | 货号 | 宿主 | 应用 |
Anti-Mouse HRP | G32-62G | Goat Polyclonal | WB, ELISA |
Anti-Rabbit HRP | G33-62G | Goat Polyclonal | WB, ELISA |
6、Tag标签抗体
品名 | 货号 | 宿主 | 应用 |
Anti-DYKDDDDK | F51-61M | Mouse, IgG2b, FG4R | WB, ELISA, IP, IS |
Anti-DYKDDDDK | F51-63R | Rabbit | WB |
Anti-GFP | G46-60M | Mouse, IgG1, GF28R | WB |
Anti-GST | G52-61M | Mouse, IgG2a, G2R | WB |
Anti-HA | H98-61M | Mouse, IgG3, C10 | WB, ELISA, IP, IS |
Anti-HA | H98-63R | Rabbit Polyclonal | WB, ELISA, IP, IS |
Anti-His | H99-61M | Mouse, IgG2b, EH158 | WB, ELISA, IP, IS |
Anti-His | H99-63R | Rabbit | WB, ELISA, IP, IS |
Anti-Myc | M86-61M | Mouse, IgG1, M19 | WB, ELISA, IP, IS |
Anti-RFP | R46-61M | Mouse, IgG1, RF5R | WB |
Anti-V5 | V05-61M | Mouse, IgG1, V4RR | WB, ELISA, IP, IS |
三、生物制剂产品系列
1、表观遗传酶激活剂
品名 | 货号 | CAS 注册号 | 分子式 | 纯度 |
BML-278 | S35-904C | N/F | C24H25NO4 | >98% (TLC) |
CTPB | P07-903 | 586976-24-1 | C31H43ClF3NO2 | 98% |
Resveratrol | S35-904 | 501-36-0 | C14H12O3 | >98% |
SirtAct | S35-904E | 839699-72-8 | C20H25N5O2 | 98% (TLC) |
2、表观遗传酶抑制剂
该产品系列共包括33款表观遗传研究酶类的抑制剂，下表仅列部分产品
品名 | 货号 | 应用 |
2’-Deoxy-5-fluorocytidine | D353-904D | 不可逆DNA甲基转移酶抑制剂 |
5-Azacytidine | D353-904 | DNA低甲基化试剂 |
AK-7 | S36-904 | SIRT2抑制剂 |
APICIDIN | H83-904B | HDAC抑制剂 |
BIX-01294 3HCl | S344-903 | Histone甲基转移酶抑制剂 |
BML-210 | H83-904C | HDAC抑制剂 |
C-646 | K311-903 | HAT抑制剂 |
Chaetocin | K421-904C | Ly甲基转移酶抑制剂 |
CPTH2 | K311-903B | HAT 抑制剂 |
3、激酶激活剂
品名 | 货号 | CAS 注册号 | 分子式 | 纯度 |
8-pCPT-2-O-Me-cAMP-AM | R46-905 | 1152197-23-3 | C20H21ClN5O8PS | >97% (HPLC) |
AICAR | P47-900B | 2627-69-2 | C9H14N4O5 | >99% (TLC); NMR (Conforms) |
4、激酶抑制剂
该产品系列共包括80款常用激酶抑制剂，下表仅列部分产品
品名 | 货号 | 应用 |
6BIO | G08-900 | GSK3 inhibitor |
A83-01 | A09-900 | ALK inhibitor |
AAL-993 | F11-900C | VEGF inhibitor |
AG-1296 | P12-900 | PDGFR Inhibitor |
AG-1478 | E10-900B | EGFR inhibitor |
AG-1517 | K11-900B | Tyrosine kinase inhibitor |
5、磷酸酶抑制剂
品名 | 货号 | CAS 注册号 | 分子式 | 纯度 |
Cantharidin | P16-902C | 56-25-7 | C10H12O4 | >98% (HPLC) |
EX-527 | S35-904F | 49843-98-3 | C13H13ClN2O | 98% (TLC) |
NSC-663284 | C04-902 | 383907-43-5 | C15H16ClN3O3 | >98% |
Okadaic acid, free acid | P16-902 | 78111-17-8 | C44H68O13 | >98% (TLC) |
6、内参siRNA
品名 | 货号 |
beta-Actin Positive Control siRNA | A03-911D |
Cy3 Labeled Negative Control siRNA | S02-910N |
FAM Labeled Negative Control siRNA | S03-910N |
GAPDH Positive Control siRNA | G13-911B |
Unlabeled Negative Control siRNA | S01-910N |
7、激酶研究常用siRNA
该产品系列共包括782款常用激酶的siRNA，下表仅列部分产品
品名 | 货号 |
14-3-3 alpha/beta siRNA Set I | Y71-911 |
14-3-3 epsilon siRNA Set I | Y75-911 |
14-3-3 sigma siRNA Set I | Y86-911 |
14-3-3 theta siRNA Set I | Y84-911 |
14-3-3 zeta siRNA Set I | Y92-911 |
4EBP1 siRNA Set I | E35-911 |
AATK siRNA Set I | A02-911 |
ABL1 siRNA Set I | A03-911 |
ABL2 siRNA Set I | A04-911 |
ACK siRNA Set I | A05-911 |
ACVR2A siRNA Seti | A35-911 |
四、信号通路蛋白及酶
该产品系列包括目前常用的信号通路蛋白及相关酶类，品种多种多样，包括：乙酰/甲基转移酶系列、适配蛋白系列、凋亡通路系列、精氨酸脱亚氨酶系列、细胞周期蛋白系列、细胞应激及分子伴侣蛋白系列、去乙酰化/甲基化酶系列、二氢嘧啶酶系列、双加氧酶系列、果糖激酶系列、G-蛋白家族产品系列、激酶突变体产品系列、蛋白激酶产品系列、脂质氧化酶系列、微管/肌动蛋白相关蛋白产品系列、磷脂酶C家族产品系列、超氧化物歧化酶产品系列、Tau蛋白及其相关产品系列、转录因子产品系列、泛素蛋白产品系列以及无活性激酶产品系列。
五、信号通路相关检测试剂
该产品系列包括检测试剂、脂类酶底物、寡氨酸底物、肽底物、蛋白酶底物等产品系列。
六、胞外配体蛋白
该产品系列包括细胞趋化因子、细胞因子及生长因子（生长因子共134种，下表仅列部分）。
品名 | 货号 | 应用 |
IP-10 | I838-40N | Cell Assay |
RANTES (CCL5) | R801-40N | Cell Assay |
SDF-1 | S821-40N | Cell Assay |
IFN-gamma | I837-40N |
|
TNF-alpha | T860-40N |
|
TNF-beta | T861-40BG |
|
TNFB | T861-40N |
|
TRAIL | T880-40N |
|
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